Welcome to the Mitochondrial Phospholipid Research Center

THE CLAYPOOL LAB

where science is FUN and RIGOROUS

Johns Hopkins university




The  Johns Hopkins School of Medicine is the original research-driven  hospital. We have an established and rich tradition of training the next  generation of doctors and scientists that continues to this day.

Johns Hopkins university




The  Johns Hopkins School of Medicine is the original research-driven  hospital. We have an established and rich tradition of training the next  generation of doctors and scientists that continues to this day.

DEPARTMENT OF PHYSIOLOGY

 

Mission Statement

The research mission of the Department of Physiology is to explore how the complex cellular phenotypes that underlie the integrated functions of the tissues and organ systems comprising higher living organisms, emerge from the genomic code. Our research program extends from computational methods to developmental genetics and post-genomic strategies—from bacteria and yeast, to zebrafish, mouse, and man. http://physiology.bs.jhmi.edu/

DEPARTMENT OF PHYSIOLOGY

 

Mission Statement

The research mission of the Department of Physiology is to explore how the complex cellular phenotypes that underlie the integrated functions of the tissues and organ systems comprising higher living organisms, emerge from the genomic code. Our research program extends from computational methods to developmental genetics and post-genomic strategies—from bacteria and yeast, to zebrafish, mouse, and man. http://physiology.bs.jhmi.edu/

What can we do you for?

We Welcome You

Welcome  to The Mitochondrial Phospholipid Research Center  a.k.a. The CLAYPOOL  Lab in the Department of Physiology at the Johns Hopkins  University  School of Medicine. 

We are an eclectic group of scientists who recognize   that phospholipids are really, really, really important. Although  second in the  cell with respect to its lipid synthesizing capacity, the  mitochondrion is number  one in our hearts. Using biochemical and cell  biologic approaches, we seek to comprehensively  understand any and all  aspects of mitochondrial phospholipid metabolism as it  relates to human  health and disease. 

Frequent Ask Questions

  What is your lab philosophy?

To  identify important biological questions and then  develop comprehensive and  clever strategies to establish likely  answers.   In other words, don’t suck.

How did your lab become a research center?
As a  group, we made the decision that we were in fact not just a lab, but a center.       
Dr. Claypool, how do you explain your dearth of awards?
 Once  you meet me, you’ll understand.

Opportunities

Postdoctoral Fellows:  We currently are recruiting one postdoctoral  fellow. A suitable  candidate will have an established expertise in  biochemistry, cell  biology, or biophysics; familiarity with the fields of  mitochondrial  biology or lipid metabolism; excellent communication skills in  English;  and a strong publication record. Postdoctoral fellows interested in   seeking independent funding are particularly encouraged to apply.  Interested  candidates should send a CV, brief summary of research  experience and  interests, and the names of three references to Prof.  Steven Claypool.   

Graduate Students: Motivated rotons are always welcome. We seek to  integrate 1-2 new graduate students into our group.

What's Happening!?!?

PUBLICATIONS

 Steffen J, Vashisht AA, Wan J, Jen JC, Claypool SM, Wohlschlegel JA, Koehler CM. Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2 mediated hyperfusion of mitochondria. Molecular Biology of the Cell. 2017 Mar 1;28(5):600-612. PMCID: PMC5328619 

 Lu YW, Acoba MG, Selvaraju K, Huang TC, Nirujogi RS, Sathe G, Pandey A, Claypool SMHuman adenine nucleotide translocases physically and functionally interact with respirasomes. Mol Biol Cell. 2017 Apr 12. pii: mbc.E17-03-0195. 

STUDENTS

Summer Intern: Kiyea Milledge, a Senior in High School from the Johns Hopkins SARE (Summer Academic Research Experience) program is visiting our lab for the summer.

http://sare.cellbio.jhmi.edu/


We welcome Erica Avery INTO our lab!!! We are increasing in numbers and impacts.

CELEBRATIONS

PSam received an award from the NSF Graduate Research Fellowship Program (GRFP) and passed his Oral Examination. Tremendous work, official PhD candidate!!!!

Contact Us

Better yet, see us in person!

Claypool Lab

1915 E Madison St, Baltimore, Maryland 21205, United States

Where science is FUN and RIGOROUS

Principal Investigator

Steven Claypool, Ph.D.

Associate Professor of Physiology
 Department of Physiology
725 N. Wolfe Street
   Hunterian Building, Room 205
Baltimore, MD 21205
Phone 410.614.1786