where science is FUN and RIGOROUS

Welcome to the Mitochondrial Phospholipid Research Center

What can we do you for?

We Welcome You


Welcome  to The Mitochondrial Phospholipid Research Center  a.k.a. The CLAYPOOL  Lab in the Department of Physiology at the Johns Hopkins  University  School of Medicine. 

We are an eclectic group of scientists who recognize   that phospholipids are really, really, really important. Although  second in the  cell with respect to its lipid synthesizing capacity, the  mitochondrion is number  one in our hearts. Using biochemical and cell  biologic approaches, we seek to comprehensively  understand any and all  aspects of mitochondrial phospholipid metabolism as it  relates to human  health and disease. 

Frequent Ask Questions


  What is your lab philosophy?

To  identify important biological questions and then  develop comprehensive and  clever strategies to establish likely  answers.   In other words, don’t suck.

How did your lab become a research center?
As a  group, we made the decision that we were in fact not just a lab, but a center.       

Dr. Claypool, how do you explain your dearth of awards?
 Once  you meet me, you’ll understand.



Graduate Students: Motivated rotons are always welcome. We seek to  integrate 1-2 new graduate students into our group.

Postdoctoral Fellows:  We currently are recruiting one postdoctoral  fellow. A suitable  candidate will have an established expertise in  biochemistry, cell  biology, or biophysics; familiarity with the fields of  mitochondrial  biology or lipid metabolism; excellent communication skills in  English;  and a strong publication record. Postdoctoral fellows interested in   seeking independent funding are particularly encouraged to apply.  Interested  candidates should send a CV, brief summary of research  experience and  interests, and the names of three references to Prof.  Steven Claypool.   

What's Happening!?!?


  • Sam PN, Avery E, Claypool SM. Proteolytic Control of Lipid Metabolism. ACS Chemical Biology. 2019 Sep 30. doi: 10.1021/acschembio.9b00695.
  • Calzada E, Avery E, Sam PN, Modak A, Wang C, McCaffery JM, Han X, Alder NN, Claypool SM. Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function. Nature Communications. 2019 Mar 29;10(1):1432.


  • PSam's inspirational story is published in ASBMB Today. Great read and well worth a gander.
  • PSam and Erica's Review is accepted at ACS Chem. Bio. Good work!
  • We welcome a new postdoc in our team, Dr. Nanami Senoo
  • Dr. Steven Claypool gave a talk at the first Mitochondria in Health and Disease, Gordon Research Conference.
  • Congrats to PSam for receiving a Best Poster Award at the Gordon Research Conference.
  • Liz's paper that showed PE flux across the IMS to be bidirectional is accepted at Nature Communications.

Contact Us

Better yet, see us in person!

Claypool Lab

1915 E Madison St, Baltimore, Maryland 21205, United States

Where science is FUN and RIGOROUS

Principal Investigator

Steven Claypool, Ph.D.

Associate Professor of Physiology
 Department of Physiology
725 N. Wolfe Street
   Hunterian Building, Room 205
Baltimore, MD 21205
Phone 410.614.1786

Drop us a line!